Amyotrophic lateral sclerosis (ALS), often referred to as "Lou Gehrig's Disease," is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord.
Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their death. When the motor neurons die, the ability of the brain to initiate and control muscle movement is lost.
A-myo-trophic comes from the Greek language. "A" means no or negative. "Myo" refers to muscle, and "Trophic" means nourishment–"No muscle nourishment." When a muscle has no nourishment, it "atrophies" or wastes away. "Lateral" identifies the areas in a person's spinal cord where portions of the nerve cells that signal and control the muscles are located. As this area degenerates it leads to scarring or hardening ("sclerosis") in the region.
As motor neurons degenerate, they can no longer send impulses to the muscle fibers that normally result in muscle movement.
Initially, the symptoms of ALS may be so subtle that the symptoms are not even noticed. Eventually, one experiences obvious weakness and/or muscle atrophy. This is followed by twitching, cramping, or stiffness of affected muscles, and/or slurred and nasal speech. The twitching, cramping, etc. associated with ALS is a result of the dying motor neurons.
With voluntary muscle action progressively affected, patients in the later stages of the disease may become totally paralyzed.
Like virtually all neurodegenerative disorders, the cause of ALS is still undefined. However, one strong possibilty is the idea of a neurodegenerative chain-reaction which is common in all neurodegenerative disorders, in which cellular 'faults' produce or induce some type of a ‘cascade’ failure that leads to progressive neuronal loss and progressive degeneration. Given that familial ALS has been linked to a mutation on the gene coding for superoxide dismutase (a critical enzyme involved in the protection of mitochondria against oxidative stress), early work has focused on oxidative stress again, a probable mechanism in virtually all neurodegenerative disorders.
Oxidative stress is created (and managed) within the mitochondria, the primary chemical energy generation system in the cell. Most free radicals (which cause oxidative stress) are produced in the mitochondria but, there are extensive cellular defenses against this stress in the mitochondria itself (in which superoxide dismutase plays an important but not exclusive role).
A critical issue is the emerging evidence that in aging, there is probably progressive damage to mitochondrial DNA and progressive failure of the mechanisms by which the mitochondria are protected from oxidative stress. There is work suggesting that progressive damage to the mitochondria is a central mechanism in age-related change. This implies that damage to the mitochondria may be a common denominator in all age-related neurodegenerative diseases.
Failure of the mitochondria to manage oxidative stress can lead to a lot of undesirable effects, including stimulation of apoptosis (programmed cell death), damage to other cellular organelles, and disorders of protein folding (an area of increasing interest in ALS and many other neurodegenerative disorders).
Since neurons for the most part cannot be replaced (with some partial exceptions), any process that stimulates programmed cell death of motor neurons will eventually lead to negative motor symptoms and eventual motor system failure. Evidence suggests that programmed cell death may be stimulated (as a primary cause of atrophy) in both upper and lower motor neuron groups in ALS.
The onset of ALS has been linked to several factors, including: a virus; exposure to various neurotoxins or heavy metals; DNA defects; immune system abnormalities; occupational involvement in military service and elite sports (where the issue again may be toxic exposure); and enzyme abnormalities.
Surgeries involving the spinal cord have also been thought to play a role in the onset of ALS, possibly due to the increased burden of oxidative stress and inflammation after spinal cord injury or stress.
There is a known hereditary factor in familial ALS (FALS); however, there is no known hereditary component in the 90–95% cases diagnosed as sporadic ALS. An inherited genetic defect on chromosome 21 (coding for superoxide dismutase) is associated with approximately 20% of familial cases of ALS. The children of those diagnosed with familial ALS have a higher risk factor for developing the disease; however, those who have close family members diagnosed with sporadic ALS have no greater a risk factor than the general population, suggesting again an environmental or other non-genetic cause.
Some environmental causative factors have been suggested for the increased incidence in the western Pacific. Prolonged exposure to a dietary neurotoxin called BMAA is one suspected risk factor in Guam; the neurotoxin is a compound found in the seed of the cycad Cycas circinalis, a tropical plant found in Guam, which was used in the human food supply during the 1950s and early 1960s.
The very high incidence of the disease among Italian soccer players (more than five times higher than normally expected) shows a possible link between the disease and the use of pesticides on the soccer fields (several of which have been linked to neuronal toxicity).
According to the ALS Association, military veterans are at an increased risk of contracting ALS (again, possibly implying a link to neurotoxic chemical exposure). In its report ALS in the Military, the group pointed to an almost 60% greater chance of the disease in military veterans than the general population.
The former Indian Army Chief of Staff General K.Sunderji also suffered from ALS before passing away. For Gulf War veterans, the chance is seen as twice that of veterans not deployed to the Persian Gulf in a joint study by the Veterans Affairs Administration and the DOD, another epidemiologic association suggesting a link to toxic exposure.
Dietary intake of polyunsaturated fatty acids (PUFA) has been shown in several studies to decrease the risk of developing ALS and other neurodegenerative disorders, probably through several mechanisms, including promotion of neurotrophins such as BDNF
1. Conwit, Robin A. (December 2006). "Preventing familial ALS: A clinical trial may be feasible but is an efficacy trial warranted?". Journal of the Neurological Sciences 251 (1–2)
2. Al-Chalabi, Ammar; P. Nigel Leigh (August 2000). "Recent advances in amyotrophic lateral sclerosis". Current Opinion in Neurology 13 (4): 397–405. ISSN 1473-6551 PMID 10970056
4. Khabazian I, Bains JS, Williams DE, Cheung J, Wilson JM, Pasqualotto BA, Pelech SL, Andersen RJ, Wang YT, Liu L, Nagai A, Kim SU, Craig UK, Shaw CA (August 2002). Isolation of various forms of sterol beta-D-glucoside from the seed of Cycas circinalis: neurotoxicity and implications for ALS-parkinsonism dementia J. Neurochem.
5. Sla, indagini nei club. Pesticidi nel mirino" Retrieved 2008-10-02.
6. Sla, una strage nel calcio" Retrieved 2008-10-02.
7. ALS in the Military The ALS Association. 2007-05-17. Retrieved 2008-05-01.Product Suggestions That Could Help
Protocol for Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig’s Disease)
Listed below are the most important products for ALS or Lou Gehrigs’s Disease. The products are listed in order of importance so, depending upon your budget, you can decide how many to use but for best results and to have a chance at reversing it, use all these supplements.
Suggested Products - 1 month’s supply -
2 bottles per month Glutathione Specialist
3 bottles per month OCMP
3 bottles per month GeProCoQ10
Glutathione is your body's primary cellular detoxifier and antioxidant. Your liver uses it too but depleted levels always occur with chronic ill health situations.
Glutathione is an amino acid and is available in vitamins. Unfortunately, free glutathione as a supplement is not absorbed by your cells. Whether you take it in pill form or via injections, almost none gets into your cells or the liver. For years health practitioners have tried to come up with a way to get glutathione into cells. The only solution available before
Glutathione Specialist, was to consume undenatured whey protein like ImmunoPro or RenewPro. The amino acids in this type of whey can be used by the body to make glutathione. However, this process works slowly and requires that you be able to properly digest the proteins.
In Glutathione Specialist, the glutathione is hidden inside healthy fat molecules that the cells love to consume.
Consequently, glutathione gets pulled inside the cells without being broken down, where it can do its work of neutralizing toxins. I consider it a real breakthrough in detoxification, for any situation where toxins must be eliminated from the cells. Using Glutathione Specialist, you can more rapidly and effectively detoxify your cells then you can with any other product.
Ingredients: Essential phospholipids 1500 mg, reduced glutathione 500 mg, methylcoboamine (B12) 1 mg, folinic acid 800 mcg.
Other ingredients: Water, lecithin, alcohol 12%, natural flavor.
Optimize Cellular Membrane Potential (OCMP) For Enhanced Strength, Energy and Recovery.
Boosting Cell Membrane Potential improves cellular chemistry and increases overall cell efficiency.
This directly upgrades:
- Cell protection and fortification (blocking access for toxins and pathogens)
- Cell repair and recovery (increasing nutrient flow and access)
- Cell hygiene (speeding waste transfer and emission)
The key factors influencing OCMP are positive and negative ion concentrations.
These ions work together creating electrical gradients within our tissues.
These gradients are what keep cell membranes strong and determine how well the cells and nerves function.
The key elements or ions involved are sodium (Na+), potassium (K+), chloride (Cl–), and calcium (Ca2+).
These four elements are found in abundance in almost every diet but are often severely imbalanced at a cellular level.
Increasing their intake does not automatically improve CMP (Cell Membrane Potential ), indeed in many cases, CMP may actually decrease.
This proprietary OCMP formulation is doctor designed to provide therapeutic levels of what we call the ionic gatekeeper nutrients.
Among these; high levels of bio-available magnesium is key. Zinc, chromium, manganese, lithium and germanium also contribute.
These elements help spark the production and release and of calcium and chloride ions, processes essential to continued robust health.
Further, OCMP enhances the cells methylation capacity and nutritionally supports mood elevation. Daily use will positively contribute to the detoxification process and help protect the cells and brain from mercury and other neurotoxins. It augments the bodys natural pain-relief and stress recovery processes. OCMP is also a premium anti-aging nutraceutical which, through the individual and synergistic action of its ingredients, may strongly assist in the recovery of youthful function in organs, joints and skin.
Includes therapeutic levels of: Magnesium (chelated, ionic and soluble), TriMethyl Glycine (cellular repair and protection), N-Acetyl Glucosamine (intestinal, joint and skin repair and protection), Germanium 132 (cellular oxygen utilization), with supporting levels of organic lithium, selenium, zinc, iodide, vitamins and a full range of trace minerals and absorption assisting cofactors. 120 capsules
Ingredients Per 4 Capsules:Magnesium complex (Magnesium Orotate, Magnesium Chloride Hexahydrate, Magnesium AA Chelate, Magnesium Krebs) 1250 mg, Vitamin C 250 mg, Vitamin B6 208 mg, Vitamin B6 (P5P) 33 mg
Vitamin B3 17 mg, Vitamin B12 0.333 mg, Zinc Picolinate (20%) 208 mg, Vitamin E 83 mg
Manganese Citrate 42 mg, Boron (Amino Acid chelate) 33 mg, Iodine (Potassium iodide) 8 mg
Biotin 8 mg, Lithium Orotate 8 mg, Germanium 132 8 mg, Molybedenum (Amino Acid chelate) 1.7 mg, Selenium (Selenomethionine) 2 mg, GTF Chromium 2.3% 1.7 mg, Proprietary Blend 933 mg contains:
NutraFlora, Kelp, Mezotrace Minerals, Aquamin, Choline Bitartrate, Tri-Methyl-Glycine (Betaine Anhydrous), N-Acetyl-Glucosamine, Humic & Fulvic Acids, Aulterra Trace Minerals 120 Capsules
The new standard in CoQ10 supplementation. The solubility and absorbability of CoQ10 in Ge-ProCoQ10 has been increased by using esters to make it more bioavailable. Human trials show that taking it results in 18 times higher serum levels of CoQ10 than the same amount of standard CoQ10. These trials also show that at just 30 mg per day, ProCoQ10 reduced daily DNA damage in humans by 51%. The amount of ProCoQ10 in this product is 200 mg per capsule. At 18 times better absorption, this is equivalent to the amount absorbed in 3600 mg of the old style, normal CoQ10.
Ge-ProCoQ10 contains another powerful oxygenation promoting ingredient, Organic Germanium 132.
It improves cellular oxygen levels. It is an oxygen-rich organic form of germanium which has been studied for its antiviral, immuno-stimulative and free-radical scavenging actions, and for supporting improved oxygen utilization.
Studies have shown Germanium 132 protects cells against radiation damage. Since radiation damage is oxidative, this protection suggests it has strong antioxidative activity. Germanium 132 also increases the production of interferon, which helps activate immune system macrophages and T-suppressor cells, and enhances Natural Killer Cell activity. Each capsules supplies 50 mg of this organic germanium.
Each Ge-ProCoQ10-Max capsule provides 350mg Soluble Rice Bran Complex (SRBC) which is 100% usable and absorbable. It is completely digestible because only the soluble part of the stabilized rice germ and bran is used. When taking just one capsule you receive the equivalent nutrition of a pound of ordinary brown rice, without all the starch.This nutritious Rice Complex strongly supports maximum absorption of ProCoQ10 - and further enhances its far ranging benefits.
It provides a broad range of antioxidants including tocotrienols, which have been found to be six thousand times more effective than vitamin E. Also natural B-Vitamins that boost energy, stamina and help stabilize blood sugar. (Including natural B-Vitamins that cannot be synthesized such as Pangamic Acid.) It is a natural source of Alpha Lipoic Acid, and IP6.
The folks at GetHealthyAgainstore.com have all the products we recommend in this report.
To learn more about these products, you can go to GetHealthyAgainstore.com
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